Social Work Exam Human Behavior Practice Test 2025 – Complete Prep

Tofranil and Elavil are classified as tricyclic antidepressants (TCAs). This classification refers to their chemical structure, which contains three fused rings (hence "tricyclic"). TCAs work by inhibiting the reuptake of certain neurotransmitters, primarily norepinephrine and serotonin, which increases the levels of these neurotransmitters in the synaptic cleft and helps alleviate depressive symptoms.

Their efficacy in treating depression, as well as anxiety and certain chronic pain conditions, is well-documented. While other classes of antidepressants, such as monoamine oxidase inhibitors or selective serotonin reuptake inhibitors, have different mechanisms of action and chemical structures, TCAs are uniquely characterized by their three-ring structure and broad impact on various neurotransmitters. Understanding this classification is crucial for recognizing the appropriate use and potential side effects associated with the medication, which can differ significantly from those of other types of antidepressants.